Pickens Charles L, Golden Sam A, Nair Sunila G
Department of Psychological Sciences, Kansas State University, Manhattan, Kansas, USA.
Curr Protoc Neurosci. 2013 Jul;Chapter 6:Unit 6.27. doi: 10.1002/0471142301.ns0627s64.
While fear and anxiety can grow over time in anxiety disorders, most efforts to model this phenomenon with fear conditioning in rodents cause fear that remains stable or decreases across weeks or months. Here, we describe several methods to induce conditioned fear that grows over the course of 1 month and is sustained for at least 2 months using an extended fear conditioning approach. These methods include a very reliable standard method that causes multiple fear measures to increase over months, as well as alternative methods.
虽然恐惧和焦虑会在焦虑症中随时间增长，但大多数用啮齿动物恐惧条件反射来模拟这种现象的研究导致恐惧在数周或数月内保持稳定或减少。在这里，我们描述了几种使用延长恐惧条件反射方法来诱导条件性恐惧的方法，这种恐惧在1个月内增长并至少持续2个月。这些方法包括一种非常可靠的标准方法，该方法会使多种恐惧指标在数月内增加，以及其他替代方法。
