Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, China, Beijing 100190, China.
Small. 2013 Jul 22;9(14):2427-31. doi: 10.1002/smll.201300600.
Ferritin-based FAP-α-responsive fluorescence nanoprobes could be activated immediately as they penetrate the tumor blood vessels and come across the FAP-α molecules on the membrane of CAFs in the tumor microenvironment instead of reaching a certain depth into tumor tissue to interact with tumor cells. This probe may become a promising nanomaterial for highly specific and sensitive tumor imaging through responding to the enzymes in the tumor microenvironment.
基于铁蛋白的 FAP-α 响应荧光纳米探针可以在穿透肿瘤血管并遇到肿瘤微环境中 CAF 细胞膜上的 FAP-α 分子时立即被激活，而无需到达肿瘤组织的一定深度与肿瘤细胞相互作用。这种探针可能成为一种有前途的纳米材料，通过响应肿瘤微环境中的酶，实现高度特异性和敏感的肿瘤成像。
