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用于肿瘤治疗的pH响应性聚合物纳米材料

pH-Responsive Polymer Nanomaterials for Tumor Therapy.

作者信息

Chu Shunli, Shi Xiaolu, Tian Ye, Gao Fengxiang

机构信息

Department of Implantology, Hospital of Stomatology, Jilin University, Changchun, China.

Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.

出版信息

Front Oncol. 2022 Mar 22;12:855019. doi: 10.3389/fonc.2022.855019. eCollection 2022.

DOI:10.3389/fonc.2022.855019
PMID:35392227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8980858/
Abstract

The complexity of the tumor microenvironment presents significant challenges to cancer therapy, while providing opportunities for targeted drug delivery. Using characteristic signals of the tumor microenvironment, various stimuli-responsive drug delivery systems can be constructed for targeted drug delivery to tumor sites. Among these, the pH is frequently utilized, owing to the pH of the tumor microenvironment being lower than that of blood and healthy tissues. pH-responsive polymer carriers can improve the efficiency of drug delivery , allow targeted drug delivery, and reduce adverse drug reactions, enabling multifunctional and personalized treatment. pH-responsive polymers have gained increasing interest due to their advantageous properties and potential for applicability in tumor therapy. In this review, recent advances in, and common applications of, pH-responsive polymer nanomaterials for drug delivery in cancer therapy are summarized, with a focus on the different types of pH-responsive polymers. Moreover, the challenges and future applications in this field are prospected.

摘要

肿瘤微环境的复杂性给癌症治疗带来了重大挑战，同时也为靶向药物递送提供了机会。利用肿瘤微环境的特征信号，可以构建各种刺激响应型药物递送系统，以实现向肿瘤部位的靶向药物递送。其中，由于肿瘤微环境的pH值低于血液和健康组织，pH值常被用于此。pH响应型聚合物载体可以提高药物递送效率，实现靶向药物递送，并减少药物不良反应，从而实现多功能和个性化治疗。pH响应型聚合物因其有利的性质和在肿瘤治疗中的应用潜力而受到越来越多的关注。在这篇综述中，总结了pH响应型聚合物纳米材料在癌症治疗中药物递送的最新进展和常见应用，重点关注不同类型的pH响应型聚合物。此外，还展望了该领域的挑战和未来应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/eba9e67252e1/fonc-12-855019-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/dcfb280d891a/fonc-12-855019-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/b1914d56ef34/fonc-12-855019-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/edb92dfc23ff/fonc-12-855019-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/a68efebb3966/fonc-12-855019-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/9a876a0be8d2/fonc-12-855019-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/eba9e67252e1/fonc-12-855019-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/dcfb280d891a/fonc-12-855019-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/b1914d56ef34/fonc-12-855019-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/edb92dfc23ff/fonc-12-855019-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/a68efebb3966/fonc-12-855019-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/9a876a0be8d2/fonc-12-855019-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edea/8980858/eba9e67252e1/fonc-12-855019-g006.jpg

相似文献

[1]
pH-Responsive Polymer Nanomaterials for Tumor Therapy.

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[2]
A critical review on the dissemination of PH and stimuli-responsive polymeric nanoparticular systems to improve drug delivery in cancer therapy.

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[4]
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[5]
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[6]
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[9]
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[10]
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本文引用的文献

[1]
Self-assembled porphyrin polymer nanoparticles with NIR-II emission and highly efficient photothermal performance in cancer therapy.

Mater Today Bio. 2021-12-30

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Yale J Biol Med. 2021-12

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EZH2 suppresses endogenous retroviruses and an interferon response in cancers.

Genes Cancer. 2021-12-27

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Pharmaceutics. 2021-12-10

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Evaluation of the Suitability of RNAscope as a Technique to Measure Gene Expression in Clinical Diagnostics: A Systematic Review.

Mol Diagn Ther. 2022-1

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Bone Marrow Transplant. 2022-3

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Chemotherapeutic Drug-Regulated Cytokines Might Influence Therapeutic Efficacy in HCC.

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Nanomaterials (Basel). 2021-12-17

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Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma.

Curr Oncol. 2021-12-20

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