Department of Lung Cancer, Cancer Institute and Hospital of Tianjin Medical University, , Tianjin, China.
J Clin Pathol. 2013 Nov;66(11):937-45. doi: 10.1136/jclinpath-2013-201467. Epub 2013 Jul 13.
The aim of this study was to evaluate the prognostic value of E-cadherin, β-catenin, vimentin and S100A4 expression in a cohort of squamous cell lung carcinoma (SqCC) patients.
Tumours from 204 patients with surgically resected SqCC were used for the immunohistochemical analyses of E-cadherin, β-catenin, vimentin and S100A4 expression. Correlations between the expression of these markers and clinicopathological parameters were analysed using the χ(2) test. The prognostic value of these markers was evaluated using univariate Kaplan-Meier survival analyses and multivariate Cox proportional hazards model analyses.
Significant associations between E-cadherin expression and T stage (p=0.040), histological differentiation (p=0.005), lymph node metastasis (p<0.001), and recurrence (p<0.001) were identified. Decreased β-catenin expression was significantly correlated with T stage (p=0.003) and lymph node metastasis (p=0.010). Vimentin expression was associated with histological differentiation (p=0.017) and lymph node metastasis (p=0.001). Moreover, significant correlations were observed between S100A4 expression and lymph node metastasis (p=0.020) and recurrence (p<0.001). In the univariate analyses, high E-cadherin expression was a positive indicator for overall survival (OS) (p<0.001) and disease-free survival (DFS) (p<0.001), whereas high S100A4 or vimentin expression were negative indicators for OS (p<0.001 and p=0.010, respectively) and DFS (p<0.001 and p=0.006, respectively). In the multivariate analyses, E-cadherin and S100A4 expression were independent prognostic factors for OS (HR 0.697, 95% CI 0.524 to 0.926, p=0.013, and HR 1.508, 95% CI 1.122 to 2.027, p=0.007, respectively) and DFS (HR 0.634, 95% CI 0.471 to 0.852, p=0.003, and HR 1.490, 95% CI 1.101 to 2.015, p=0.010, respectively).
Effective analysis of E-cadherin and S100A4 expression may allow for the identification of patients who are at a high risk of recurrence and poor prognosis in SqCC.
本研究旨在评估 E-钙黏蛋白、β-连环蛋白、波形蛋白和 S100A4 表达在鳞状细胞肺癌 (SqCC) 患者队列中的预后价值。
对 204 例接受手术切除的 SqCC 患者的肿瘤进行了 E-钙黏蛋白、β-连环蛋白、波形蛋白和 S100A4 表达的免疫组织化学分析。使用 χ(2)检验分析这些标志物的表达与临床病理参数之间的相关性。使用单因素 Kaplan-Meier 生存分析和多因素 Cox 比例风险模型分析评估这些标志物的预后价值。
E-钙黏蛋白表达与 T 分期（p=0.040）、组织学分化（p=0.005）、淋巴结转移（p<0.001）和复发（p<0.001）显著相关。β-连环蛋白表达降低与 T 分期（p=0.003）和淋巴结转移（p=0.010）显著相关。波形蛋白表达与组织学分化（p=0.017）和淋巴结转移（p=0.001）相关。此外，S100A4 表达与淋巴结转移（p=0.020）和复发（p<0.001）显著相关。在单因素分析中，E-钙黏蛋白高表达是总生存（OS）（p<0.001）和无病生存（DFS）（p<0.001）的阳性指标，而 S100A4 或波形蛋白高表达是 OS（p<0.001 和 p=0.010）和 DFS（p<0.001 和 p=0.006）的阴性指标。在多因素分析中，E-钙黏蛋白和 S100A4 表达是 OS（HR 0.697，95%CI 0.524 至 0.926，p=0.013，和 HR 1.508，95%CI 1.122 至 2.027，p=0.007）和 DFS（HR 0.634，95%CI 0.471 至 0.852，p=0.003，和 HR 1.490，95%CI 1.101 至 2.015，p=0.010）的独立预后因素。
对 E-钙黏蛋白和 S100A4 表达的有效分析可能有助于识别 SqCC 患者中复发风险高和预后不良的患者。
