Yan Li-Feng, Gu Ai-Hua
School of Public Health, Nanjing Medical University, Nanjing, China.
Yi Chuan. 2013 Jul;35(7):856-66. doi: 10.3724/sp.j.1005.2013.00856.
The phenomenon of "tissue regeneration" has attracted numerous biologists for many years. Regenerative capacity differs greatly across species. The lower vertebrates such as zebrafish have exceptionally high regeneration abilities, while most high vertebrate species including humans do not have a remarkable ability for regeneration. It has been found zebrafish has a strong ability to regenerate a variety of tissues and organs including fins, heart, retina, optic nerve, spinal cord, liver, and sensory hair cells. Thus, we can learn useful information from the zebrafish regeneration model to understand the human regeneration defects and promote the development of regenerative medicine. This review summarizes the current research status for regeneration of heart, nerve, liver, and fin regeneration in zebrafish.
多年来，“组织再生”现象吸引了众多生物学家。不同物种的再生能力差异很大。像斑马鱼这样的低等脊椎动物具有极高的再生能力，而包括人类在内的大多数高等脊椎动物物种则没有显著的再生能力。研究发现，斑马鱼具有强大的再生多种组织和器官的能力，包括鳍、心脏、视网膜、视神经、脊髓、肝脏和感觉毛细胞。因此，我们可以从斑马鱼再生模型中获取有用信息，以了解人类的再生缺陷并促进再生医学的发展。这篇综述总结了斑马鱼心脏、神经、肝脏和鳍再生的当前研究现状。
