Suppr超能文献

[豌豆(Pisum sativum L.)中孟德尔基因克隆的研究进展及其在遗传学教学中的应用]

[Research progress on the cloning of Mendel's gene in pea (Pisum sativum L.) and its application in genetics teaching].

作者信息

He Feng-Hua, Zhu Bi-Yan, Gao Feng, Li Shao-Shan, Li Niang-Hui

机构信息

South China Normal University, Guangzhou, China.

出版信息

Yi Chuan. 2013 Jul;35(7):931-8. doi: 10.3724/sp.j.1005.2013.00931.

Abstract

One hundred and fifty years ago, Gregor Mendel investigated the segregation of seven traits in pea (Pisum sativum) and established the law of segregation and the law of independent assortment in genetics. After the two laws of genetics were rediscovered in 1900, the seven traits have been extensively investigated in the fields of plant physiology and biochemistry as well as in the cell and molecular levels. Recently, with the development of molecular technology in genetics, four genes for seed shape (R), stem length (Le), cotyledon colour (I), and flower colour (A) have been cloned and sequenced; and another three genes for immature pod colour (Gp), fasciation (Fa) and pod form (V) have been located in the linkage groups, respectively. The identification and cloning of the four Mendel's genes will help deeply understand the basic concept of gene in many respects: like the diversity of gene function, the different origins for gene mutation in molecular level, and the molecular nature of a dominant gene or a recessive gene. In teaching of genetics, the introduction of most recent research advancements of cloning of Mendel's genes to the students and the interpretation of the Mendel's laws in molecular level will help students promote their learning interests in genetics and help students grasp the whole content from classical genetics to molecular genetics and the developmental direction of this subject.

摘要

150年前,格雷戈尔·孟德尔研究了豌豆(Pisum sativum)中7个性状的分离情况,并建立了遗传学中的分离定律和自由组合定律。1900年这两个遗传学定律被重新发现后,这7个性状在植物生理学、生物化学以及细胞和分子水平等领域得到了广泛研究。最近,随着遗传学分子技术的发展,种子形状(R)、茎长度(Le)、子叶颜色(I)和花色(A)的4个基因已被克隆和测序;另外3个基因,即未成熟豆荚颜色(Gp)、多棱(Fa)和豆荚形状(V)分别被定位在连锁群中。孟德尔这4个基因的鉴定和克隆将有助于从多个方面深入理解基因的基本概念:如基因功能的多样性、分子水平上基因突变的不同起源以及显性基因或隐性基因的分子本质。在遗传学教学中,向学生介绍孟德尔基因克隆的最新研究进展,并在分子水平上解读孟德尔定律,将有助于提高学生对遗传学的学习兴趣,帮助学生掌握从经典遗传学到分子遗传学的全部内容以及该学科的发展方向。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验