IEEE Trans Biomed Circuits Syst. 2010 Aug;4(4):250-62. doi: 10.1109/TBCAS.2010.2048567.
Dependability is an important system attribute for microfluidic lab-on-chip. Robust testing methods are therefore needed to ensure correct results. Previously proposed techniques for reading test outcomes and for pulse-sequence analysis are cumbersome and error prone. We present a built-in self-test (BIST) method for digital microfluidic lab-on-chip. This method utilizes digital microfluidic logic gates to implement the BIST architecture; AND, OR and NOT gates are used to compress multiple test-outcome droplets into a single droplet to facilitate detection with low overhead. These approaches obviate the need for capacitive sensing test-outcome circuits for analysis. We also apply the BIST architecture to a pin-constrained biochip design. A multiplexed bioassay protocol is used to evaluate the effectiveness of the proposed test method.
可靠性是微流控芯片实验室的一个重要系统属性。因此，需要稳健的测试方法来确保正确的结果。以前提出的读取测试结果和脉冲序列分析的技术既繁琐又容易出错。我们提出了一种用于数字微流控芯片实验室的内置自测试（BIST）方法。该方法利用数字微流控逻辑门实现 BIST 架构；使用与门、或门和非门将多个测试结果液滴压缩成单个液滴，以便以低开销进行检测。这些方法避免了对用于分析的电容感应测试结果电路的需求。我们还将 BIST 架构应用于引脚受限的生物芯片设计。采用多路复用生物分析协议来评估所提出的测试方法的有效性。
