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数字微流控生物芯片的并行扫描式检测与多重缺陷诊断

Parallel scan-like test and multiple-defect diagnosis for digital microfluidic biochips.

出版信息

IEEE Trans Biomed Circuits Syst. 2007 Jun;1(2):148-58. doi: 10.1109/TBCAS.2007.909025.

DOI:10.1109/TBCAS.2007.909025
PMID:23851669
Abstract

Dependability is an important attribute for microfluidic biochips that are used for safety-critical applications such as point-of-care health assessment, air-quality monitoring, and food-safety testing. Therefore, these devices must be adequately tested after manufacture and during bioassay operations. We propose a parallel scan-like testing methodology for digital microfluidic devices. A diagnosis method based on test outcomes is also proposed. The diagnosis technique is enhanced such that multiple defect sites can be efficiently located using parallel scan-like testing. Defect diagnosis can be used to reconfigure a digital microfluidic biochip such that faults can be avoided, thereby enhancing chip yield and defect tolerance. We evaluate the proposed method using complexity analysis as well as applying it to a fabricated biochip.

摘要

可靠性是用于安全性关键应用的微流控生物芯片的一个重要属性,例如即时医疗评估、空气质量监测和食品安全测试。因此,这些设备在制造后和生物测定操作期间必须进行充分的测试。我们为数字微流控设备提出了一种类似并行扫描的测试方法。还提出了一种基于测试结果的诊断方法。该诊断技术得到了增强,使得可以使用类似并行扫描的测试来有效地定位多个缺陷部位。缺陷诊断可用于重新配置数字微流控生物芯片,从而避免故障,从而提高芯片产量和容错能力。我们使用复杂性分析来评估所提出的方法,并将其应用于制造的生物芯片。

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