IEEE Trans Biomed Circuits Syst. 2010 Dec;4(6):445-53. doi: 10.1109/TBCAS.2010.2078508.
A complementary metal-oxide semiconductor (CMOS)-based multichip flexible neural stimulator for retinal prostheses was developed. The multichip retinal stimulator is capable of simultaneous multisite stimulation. An on-chip stimulation generator was implemented on the "unit chip," which is the core device of the multichip retinal stimulator. The performance of the CMOS circuitry was characterized. A new device structure and packaging process was developed. The in vivo retinal stimulation on a rabbit's retina was successfully performed and the multisite stimulation functionality was confirmed.
开发了一种基于互补金属氧化物半导体 (CMOS) 的多芯片柔性神经刺激器,用于视网膜假体。多芯片视网膜刺激器能够实现同时多点刺激。片上刺激发生器在“单元芯片”上实现,这是多芯片视网膜刺激器的核心器件。对 CMOS 电路的性能进行了表征。开发了一种新的器件结构和封装工艺。在兔子的视网膜上成功地进行了体内视网膜刺激,并证实了多点刺激功能。