Fauchon F, Davila L, Chatellier G, Fohanno D, Philippon J, Rey A, Chiras J, Poisson M, Delattre J Y
Department of Radiation Therapy, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Neurosurgery. 1990 Aug;27(2):231-4. doi: 10.1097/00006123-199008000-00010.
Forty patients with malignant supratentorial gliomas were treated with surgery, intra-arterial infusions of 1-(2-hydroxyethyl)chloroethylnitrosourea, and radiation therapy. The median duration of survival was 12 months; it differed according to the histological subtype (over 30 months for patients with anaplastic astrocytomas or anaplastic oligodendroglioma and 10.5 months for glioblastoma; P = 0.0025). Serious complications of monocular blindness and leukoencephalopathy were observed in four patients (10%).
40例幕上恶性胶质瘤患者接受了手术、动脉内输注1-(2-羟乙基)氯乙基亚硝脲及放射治疗。中位生存期为12个月；生存期因组织学亚型而异（间变性星形细胞瘤或间变性少突胶质细胞瘤患者超过30个月，胶质母细胞瘤患者为10.5个月；P = 0.0025）。4例患者（10%）出现了严重并发症，包括单眼失明和白质脑病。
