Center for Traditional Chinese Medicine and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Evid Based Complement Alternat Med. 2013;2013:529458. doi: 10.1155/2013/529458. Epub 2013 Jun 18.
Xiao Chai Hu Tang (XCHT), a compound formula originally recorded in an ancient Chinese medical book Shanghanlun, has been used to treat chronic liver diseases for a long period of time in China. Although extensive studies have been demonstrated the efficacy of this formula to treat chronic hepatitis, hepatic fibrosis, and hepatocarcinoma, how it works against these diseases still awaits full understanding. Here, we firstly present an overview arranging from the entire formula to mechanism studies of single herb in XCHT and their active components, from a new perspective of "separation study," and we tried our best to both detailedly and systematically organize the antihepatocarcinoma effects of it, hoping that the review will facilitate the strive on elucidating how XCHT elicits its antihepatocarcinoma role.
小柴胡汤（XCHT），一种最初记录在古代中医书籍《伤寒论》中的复方配方，在中国长期用于治疗慢性肝病。尽管广泛的研究已经证明了该配方治疗慢性肝炎、肝纤维化和肝癌的疗效，但它如何治疗这些疾病仍有待全面了解。在这里，我们首先从“分离研究”的新视角，从整个配方到 XCHT 中单味药及其活性成分的机制研究，综述了 XCHT 的抗肝癌作用，并尝试详细系统地组织 XCHT 的抗肝癌作用，希望这篇综述将有助于阐明 XCHT 发挥其抗肝癌作用的机制。
