Zeng Ni, Bayan Jennifer-Ann, He Lina, Stiles Bangyan
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.
Open Endocrinol J. 2010;4:23-32. doi: 10.2174/1874216501004010023.
This paper describes the biological functions of PTEN and the PTEN regulated signaling pathway in pancreatic β-cells. PTEN has been shown to regulate the regeneration of β-cells. We review the pathways that are controlled by PTEN signaling and their functions in β-cell regeneration. In particular, we describe the unique effect of deletion in β-cells. Unlike its effect in other tissues, deletion does not lead to tumor formation but does enhance β-cell proliferation and function. In addition to the literature review, we also report new results exploring PTEN loss in adult β-cells. We demonstrate that inducing PTEN loss in adult cells has the same regenerative effects previously found for prenatal deletion.
本文描述了PTEN在胰腺β细胞中的生物学功能以及PTEN调控的信号通路。已证明PTEN可调节β细胞的再生。我们综述了由PTEN信号控制的通路及其在β细胞再生中的功能。特别是，我们描述了β细胞中PTEN缺失的独特作用。与它在其他组织中的作用不同，PTEN缺失不会导致肿瘤形成，但会增强β细胞的增殖和功能。除了文献综述，我们还报告了探索成年β细胞中PTEN缺失的新结果。我们证明，在成年细胞中诱导PTEN缺失具有与产前PTEN缺失先前发现的相同的再生作用。
