Garside P, Behnke J M, Rose R A
Department of Zoology, University of Nottingham.
Parasite Immunol. 1990 May;12(3):247-58. doi: 10.1111/j.1365-3024.1990.tb00952.x.
A laboratory model of acquired immunity to human hookworm is described. Significant resistance to challenge infection with Ancylostoma ceylanicum was elicited in mature DSN hamsters. The serum and mucosal antibody responses were investigated in both quantitative and qualitative terms and changes associated with immunity were identified. Marked differences in numbers of mast and goblet cells in the small intestine were also recorded and related to the immune status of the host.
本文描述了一种获得性人体钩虫免疫力的实验室模型。成熟的DSN仓鼠对锡兰钩虫激发感染产生了显著抗性。从定量和定性两方面研究了血清和黏膜抗体反应，并确定了与免疫相关的变化。还记录了小肠中肥大细胞和杯状细胞数量的显著差异，并将其与宿主的免疫状态相关联。
