Dopff C, Mertes P M, Nace L, Gerard A, Voiriot P, Preiss M A, May T, Canton P, Dureux J B
Département des Maladies Infectieuses et Tropicales, CHU Nancy, Hôpitaux de Brabois, Vandoeuvre-les-Nancy.
Pathol Biol (Paris). 1990 Jun;38(5 ( Pt 2)):526-9.
The aim of this study was to assess the clinical efficacy of a combination of penicillin G and ofloxacin in the treatment of community acquired pneumonia. Thirty eight patients (23 males, 15 females, mean age 62.8 years +/- 19.6) were included. They presented a CAP with the following criteria: fever, abnormal chest X-ray pattern. They received the combination of IV penicillin 12 x 10(6) U daily and IV ofloxacin 200 mg bid. After 48 hours of apyrexia, this treatment was followed by oral ofloxacin alone 200 mg bid. In six cases, the etiologic agent was identified: 2 S. pneumoniae, 1 Chlamydiae psittaci, 2 Staphylococcus aureus, 1 Mycoplasma. In 32 cases, the bacteriological investigation was negative. Five patients were excluded: 2 deaths due to heart failure, 3 alterations of treatment. Twenty eight patients recovered: apyrexia was obtained in 3.5 days. Penicillin G was prescribed for 7.5 days +/- 2.65, followed by ofloxacin alone for 11.43 +/- 3 days. Five patients were considered as clinical failures: 2 deaths due to extensive pneumonia, 3 recoveries after alteration of treatment. Side effects were rare: 1 confusion, 2 skin rashes. As a conclusion: penicillin G and ofloxacin in combination for the initial therapy of CAP, rapidly relayed by ofloxacin alone, permitted 84.3% of recovery in our patients.
本研究的目的是评估青霉素G与氧氟沙星联合治疗社区获得性肺炎的临床疗效。纳入了38例患者（男性23例，女性15例，平均年龄62.8岁±19.6岁）。他们符合以下标准的社区获得性肺炎：发热、胸部X线异常。他们接受每日静脉注射青霉素12×10⁶U和静脉注射氧氟沙星200mg，每日两次的联合治疗。在无热48小时后，该治疗之后单独口服氧氟沙星200mg，每日两次。6例中确定了病原体：2例肺炎链球菌、1例鹦鹉热衣原体、2例金黄色葡萄球菌、1例支原体。32例中细菌学检查为阴性。5例患者被排除：2例死于心力衰竭，3例治疗变更。28例患者康复：3.5天内实现无热。青霉素G使用7.5天±2.65天，之后单独使用氧氟沙星11.43天±3天。5例患者被视为临床失败：2例死于广泛肺炎，3例在治疗变更后康复。副作用少见：1例意识模糊，2例皮疹。结论：青霉素G与氧氟沙星联合用于社区获得性肺炎的初始治疗，之后迅速单独使用氧氟沙星，使我们的患者中有84.3%康复。
