Turraea pubescens 中的新甾体和倍半萜。
New steroids and sesquiterpene from Turraea pubescens.
机构信息
Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
出版信息
Fitoterapia. 2013 Oct;90:119-25. doi: 10.1016/j.fitote.2013.07.006. Epub 2013 Jul 13.
Four new compounds, including three new steroids (1-3) and one new sesquiterpene (6), and two new natural products (4-5), as well as three known steroids (7-9) were isolated from the twigs of Turraea pubescens. Compounds 3-5 are C₂₂ steroids isolated from the Meliaceae family for the first time. Their structures were elucidated by extensive NMR and MS analyses. Compound 1 exhibited inhibitory activity against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cells with an IC₅₀ value of 11.5 μM.
从毛叶山桐子的嫩枝中分离得到了 4 种新化合物，包括 3 种新甾体（1-3）和 1 种新倍半萜（6），以及 2 种新天然产物（4-5），此外还有 3 种已知甾体（7-9）。化合物 3-5 是首次从楝科中分离得到的 C₂₂甾体。通过广泛的 NMR 和 MS 分析确定了它们的结构。化合物 1 对 RAW264.7 细胞中脂多糖（LPS）诱导的一氧化氮（NO）生成具有抑制活性，IC₅₀值为 11.5 μM。
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