Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium.
Curr Opin Pharmacol. 2013 Oct;13(5):813-20. doi: 10.1016/j.coph.2013.06.008. Epub 2013 Jul 12.
When new compounds targeting the brain are developed, it is important to assess both the acute and chronic effects on brain functioning. This can be done non-invasively using a technique called functional magnetic resonance imaging (fMRI). This review discusses the possibilities of both stimulation-based and resting state fMRI to study pharmacological modulations of the rodent brain. Moreover, attention is given to the use of anesthetics which could importantly influence the outcome of both techniques.
当开发针对大脑的新化合物时，评估它们对大脑功能的急性和慢性影响非常重要。这可以通过一种称为功能磁共振成像（fMRI）的非侵入性技术来完成。本综述讨论了基于刺激和静息状态 fMRI 的可能性，以研究啮齿动物大脑的药物调制。此外，还注意到了麻醉剂的使用，这可能会对这两种技术的结果产生重要影响。
