Servicio de Neumología, Hospital Maciel, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Arch Bronconeumol. 2013 Nov;49(11):468-74. doi: 10.1016/j.arbres.2013.05.003. Epub 2013 Jul 13.
Comorbidities are common in patients with chronic obstructive pulmonary disease (COPD), and have a significant impact on health status and prognosis. The PLATINO study provides data on self-reported comorbidities and perceived health status in COPD subjects.
PLATINO is a population-based study on COPD prevalence in five Latin American cities. COPD diagnosis was defined by GOLD criteria (FEV1/FVC<.70 post-bronchodilator). Information was collected on the following comorbidities: heart disease, hypertension, diabetes, cerebrovascular disease, peptic ulcer and asthma. Health status was evaluated using the SF-12 questionnaire, derived from the question: «In general, would you say your health is excellent, very good, good, fair or poor?». A simple comorbidity score was calculated by adding the total number of comorbid conditions.
Of a total population of 5314individuals, 759 had COPD. Reported comorbidities by decreasing frequency were: any cardiovascular disease, hypertension, peptic ulcer, heart disease, diabetes, cerebrovascular disease, asthma and lung cancer. COPD patients had a higher comorbidity score and prevalence of lung cancer (P<.0001) and asthma (P<.0001), as well as a higher tendency to have hypertension (P=.0652) and cerebrovascular disease (P=.0750). Factors associated with comorbidities were age, body mass index (BMI) and female gender. The number of comorbidities increased as the health status deteriorated.
In the PLATINO population-based study, COPD individuals had an increased number of comorbidities. Age, female gender and higher BMI were the factors associated with comorbidity in these patients. Comorbid conditions were associated with impaired health status, independently of the COPD status.
慢性阻塞性肺疾病（COPD）患者常合并多种疾病，对健康状况和预后有重大影响。PLATINO 研究提供了 COPD 患者自我报告的合并症和健康感知数据。
PLATINO 是一项针对五个拉丁美洲城市 COPD 患病率的基于人群的研究。COPD 诊断根据 GOLD 标准（支气管扩张剂后 FEV1/FVC<.70）定义。收集了以下合并症的信息：心脏病、高血压、糖尿病、脑血管疾病、消化性溃疡和哮喘。健康状况采用 SF-12 问卷进行评估，问题为：“总的来说，你认为自己的健康状况是极好、很好、好、一般还是差？”。通过将合并症的总数相加来计算简单的合并症评分。
在总共 5314 名个体中，有 759 人患有 COPD。报告的合并症频率依次降低为：任何心血管疾病、高血压、消化性溃疡、心脏病、糖尿病、脑血管疾病、哮喘和肺癌。COPD 患者的合并症评分和肺癌患病率（P<.0001）以及哮喘患病率（P<.0001）更高，且高血压（P=.0652）和脑血管疾病（P=.0750）的患病趋势更高。与合并症相关的因素是年龄、体重指数（BMI）和女性性别。随着健康状况的恶化，合并症的数量增加。
在 PLATINO 基于人群的研究中，COPD 患者合并症的数量增加。年龄、女性性别和更高的 BMI 是这些患者合并症的相关因素。合并症与健康状况受损有关，与 COPD 状态无关。
