西班牙裔人群的围产期因素与乳腺癌风险
Perinatal factors and breast cancer risk among Hispanics.
作者信息
Sanderson Maureen, Pérez Adriana, Weriwoh Mirabel L, Alexander Leah R, Peltz Gerson, Agboto Vincent, O'Hara Heather, Khoder Waseem
机构信息
School of Graduate Studies and Research, Meharry Medical College, Nashville, TN 37208, USA.
出版信息
J Epidemiol Glob Health. 2013 Jun;3(2):89-94. doi: 10.1016/j.jegh.2013.02.004. Epub 2013 Mar 13.
PURPOSE
This study assessed whether perinatal factors were associated with breast cancer among Hispanics, a group with fairly low incidence rates of breast cancer.
METHODS
Data were used from a case-control study of breast cancer among Hispanics aged 30-79 conducted between 2003 and 2008 on the Texas-Mexico border. In-person interviews were completed with 188 incident breast cancer cases ascertained through surgeons and oncologists, and 974 controls (with respective response rates of 97% and 78%).
RESULTS
Relative to birth weight 2500-3999g, there was no elevation in breast cancer risk for birth weight of ≥ 4000g (odds ratio [OR] 0.76, 95% confidence interval [CI] 0.47-1.21).
CONCLUSIONS
The results tended to differ slightly from previous studies of this topic perhaps owing to the different hormonal milieu among Hispanics relative to Caucasians, African Americans and Asians in whom all previous studies of this topic have been conducted. Confirmation of these findings in larger studies may assist in determining how hormonal mechanisms responsible for breast cancer differ by ethnicity.
目的
本研究评估围产期因素是否与西班牙裔人群的乳腺癌相关，该人群乳腺癌发病率相对较低。
方法
数据来自2003年至2008年在得克萨斯 - 墨西哥边境开展的一项针对30 - 79岁西班牙裔人群乳腺癌的病例对照研究。通过外科医生和肿瘤学家确定了188例新发乳腺癌病例，并对其进行了面对面访谈，同时选取了974名对照（应答率分别为97%和78%）。
结果
与出生体重2500 - 3999克相比，出生体重≥4000克的乳腺癌风险未升高（比值比[OR]为0.76，95%置信区间[CI]为0.47 - 1.21）。
结论
该结果可能因西班牙裔人群与之前开展此主题研究的白种人、非裔美国人和亚洲人相比，激素环境不同，而与之前关于该主题的研究结果略有差异。在更大规模研究中对这些发现进行验证，可能有助于确定导致乳腺癌的激素机制如何因种族而异。
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