神经突再生的时空动态。
Spatial and temporal dynamics of neurite regrowth.
机构信息
Division of Biological Sciences, Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA; Biology Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.
出版信息
Curr Opin Neurobiol. 2013 Dec;23(6):1011-7. doi: 10.1016/j.conb.2013.06.009. Epub 2013 Jul 12.
Abstract
Injury to mature neurites triggers a series of events that have both growth promoting and inhibitory roles. Recent evidence from a variety of experimental models has revealed new neuronal re-growth modulators. The action of these modulators must be precisely regulated both in time and space, and involves multiple cellular processes including retrograde signaling and local translation in the injured neurite. New genetic techniques, in combination with pharmacological approaches, have served to advance mechanistic dissection of neuronal response to injury. Better understanding of the spatio-temporal cues would greatly aid in the development of effective regenerative therapies.
摘要
成熟神经突的损伤会引发一系列具有促进和抑制作用的事件。最近，各种实验模型的证据揭示了新的神经元再生调节剂。这些调节剂的作用必须在时间和空间上精确调节，涉及多个细胞过程，包括逆行信号转导和损伤神经突中的局部翻译。新的遗传技术与药理学方法相结合，有助于推进对神经元损伤反应的机制剖析。更好地理解时空线索将极大地有助于开发有效的再生治疗方法。
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