Küper M, Zöller M, Liebeskind S, Wiltfang J, Benninghoff J
Klinik für Neurologie, Universität Duisburg-Essen.
Fortschr Neurol Psychiatr. 2013 Jul;81(7):e14-6. doi: 10.1055/s-0033-1335612. Epub 2013 Jul 15.
A 64-year-old right-handed Caucasian presented with a four-year history of word-finding deficits and otherwise fluent speech production. Neurological examination remained unremarkable apart from the word finding impairment. Likewise, neuropsychological evaluation confirmed significantly reduced semantic word fluency. While brain MRI depicted only discrete anterior temporal atrophy, 18-fluorodeoxyglucose PET showed clear hypometabolism of the anterior temporal pole bilaterally with left predominance. An imaging-supported diagnosis of the semantic variant of primary progressive aphasia was established in close accordance to recently published diagnostic criteria.The PET findings can be regarded as typical for this condition and PET imaging proved helpful to delineate other variants (non-fluent and logopenic) of primary progressive aphasia.
一名64岁的右利手白种人患者，有4年的找词困难病史，言语表达流畅。除找词障碍外，神经系统检查无异常。同样，神经心理学评估证实语义性词语流畅性显著降低。脑部MRI仅显示颞叶前部散在萎缩，而18氟脱氧葡萄糖PET显示双侧颞极前部明显代谢减低，以左侧为主。根据最近发表的诊断标准，确诊为影像学支持的原发性进行性失语语义变异型。PET检查结果可视为该病的典型表现，PET成像有助于区分原发性进行性失语的其他变异型（非流畅型和音韵性失语型）。
