Departments of Neurology.
Radiology.
Alzheimer Dis Assoc Disord. 2021;35(2):160-163. doi: 10.1097/WAD.0000000000000429.
Parosmia, defined as the distorted perception of an odor stimulus, has been reported to be associated with head trauma, upper respiratory tract infections, sinonasal diseases, and toxin/drug consumption. To date, little is known about parosmia in right-lateralized semantic variant primary progressive aphasia. A 60-year-old right-handed man presented with a 2-year history of parosmia and prosopagnosia. Brain magnetic resonance imaging demonstrated severe atrophy of the right anterior and mesial temporal lobe, particularly in the fusiform cortex and the regions known as the primary olfactory cortex. 18F-fluorodeoxyglucose position emission tomography showed asymmetric hypometabolism of the bilateral temporal lobes (right > left). We clinically diagnosed him with right-lateralized semantic variant primary progressive aphasia. As the right hemisphere is known to be more involved in the processing of pleasant odors than the left hemisphere, we speculate that the unique manifestation of parosmia observed in this patient might be associated with the lateralization of the olfactory system.
幻嗅，定义为嗅觉刺激的扭曲感知，据报道与头部创伤、上呼吸道感染、鼻-鼻窦疾病和毒素/药物消耗有关。迄今为止，对于右侧语义变异型原发性进行性失语症中的幻嗅知之甚少。一位 60 岁的右利手男性出现幻嗅和面容失认症 2 年。脑磁共振成像显示右侧前颞叶和内侧颞叶严重萎缩，特别是在梭状回和被称为初级嗅觉皮层的区域。18F-氟脱氧葡萄糖位置发射断层扫描显示双侧颞叶（右侧>左侧）不对称低代谢。我们临床诊断他为右侧语义变异型原发性进行性失语症。由于众所周知，右半球比左半球更参与愉快气味的处理，我们推测该患者观察到的幻嗅的独特表现可能与嗅觉系统的偏侧化有关。
