Hao Liang, Yu Ri-sheng, Cui Feng, Ren Xing-chang, Xu Hai-bin, Xu Kun-yuan
Department of Radiology, the Traditional Chinese Medical Hospital, Hangzhou 310007, China.
Zhonghua Yi Xue Za Zhi. 2013 Mar 19;93(11):819-23.
To evaluate the magnetic resonance (MR) imaging findings of breast cancer subtypes based on the profiles of ER/PR and Her2.
A retrospective study was conducted for 267 breast cancer subjects between February 2007 and January 2011. Clinicopathologic features and MR imaging findings of four subtypes were compared. The Chi-square (χ(2)) test, Fisher's exact test and χ(2) section method were employed for categorical variables.
MR imaging findings:Patients with segment or linear enhancement type accounted for 25.6% in ER/PR(+), Her2(+) subtype group and 36.1% in ER/PR(-), Her2(+) subtype, no significant difference existed between them (χ(2) = 1.112, P = 0.641). But they were significantly higher than ER/PR(+), Her2(-) subtype group and ER/PR(-), Her2(-) subtype group (χ(2) = 32.793, P < 0.001; χ(2) = 14.565, P < 0.001). ER/PR(-), Her2(-) subtype patients accounted for 14.6% of the total breast cancer patients (39/267). Subjects with ER/PR(-), Her2(-) subtype were more likely to present unifocal (91.7%, 33/36) and mass type lesion (92.3%, 36/39). The mass type lesions in ER/PR(-), Her2(-) subtype group were more likely to showed smooth margin [58.3% (21/36), P < 0.001], very high intratumoral signal and peripheral hyperintense pattern on fat suppression T2-weighted imaging (P < 0.001) and early rim enhancement [81.5% (29/36), P < 0.001]. No significantly difference of four subtypes were found on number of mass, mass shape and pattern at dynamic enhancement imaging (χ(2) = 1.413, P = 0.713; χ(2) = 8.423, P = 0.204; χ(2) = 4.657, P = 0.540).
Segment or linear enhancement type is characterized by MR imaging. Early rim enhanced mass is ER/PR(-), Her2(-) breast cancer. The most important characteristics of MR imaging include a smooth edge of breast mass, very high intratumoral signal on fat suppression T2-weighted imaging and peripheral hyperintense pattern.
基于雌激素受体（ER）/孕激素受体（PR）和人表皮生长因子受体2（Her2）的表达情况评估乳腺癌亚型的磁共振（MR）成像表现。
对2007年2月至2011年1月期间的267例乳腺癌患者进行回顾性研究。比较四种亚型的临床病理特征和MR成像表现。分类变量采用卡方（χ²）检验、Fisher精确检验和χ²分割法。
MR成像表现：节段性或线性强化型患者在ER/PR(+)、Her2(+)亚型组中占25.6%，在ER/PR(-)、Her2(+)亚型组中占36.1%，两组间差异无统计学意义（χ² = 1.112，P = 0.641）。但它们显著高于ER/PR(+)、Her2(-)亚型组和ER/PR(-)、Her2(-)亚型组（χ² = 32.793，P < 0.001；χ² = 14.565，P < 0.001）。ER/PR(-)、Her2(-)亚型患者占乳腺癌患者总数的14.6%（39/267）。ER/PR(-)、Her2(-)亚型的受试者更易出现单灶性病变（91.7%，33/36）和肿块型病变（92.3%，36/39）。ER/PR(-)、Her2(-)亚型组的肿块型病变更易表现为边缘光滑[58.3%（21/36），P < 0.001]，在脂肪抑制T2加权成像上肿瘤内信号极高且呈周边高信号模式（P < 0.001）以及早期边缘强化[81.5%（29/36），P < 0.001]。在动态增强成像上，四种亚型在肿块数量、肿块形态和强化方式方面差异无统计学意义（χ² = 1.413，P = 0.713；χ² = 8.423，P = 0.204；χ² = 4.657，P = 0.540）。
节段性或线性强化型为MR成像特征。早期边缘强化的肿块为ER/PR(-)、Her2(-)型乳腺癌。MR成像的最重要特征包括乳腺肿块边缘光滑、脂肪抑制T2加权成像上肿瘤内信号极高以及周边高信号模式。
