Kawashima Hiroko, Inokuchi Masafumi, Furukawa Hiroyuki, Ikeda Hiroko, Kitamura Seiko
Department of Quantum Medical Technology, Graduate School of Medical Science, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942 Japan ; Section of Breast Oncology, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641 Japan.
Section of Breast Oncology, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641 Japan.
Springerplus. 2014 May 9;3:240. doi: 10.1186/2193-1801-3-240. eCollection 2014.
The purpose of this study was to evaluate the magnetic resonance imaging (MRI) features of breast cancer according to intrinsic subtypes and to investigate whether the MRI and immunohistochemical findings were related to neoadjuvant chemotherapy (NAC) effects.
The MRI in 116 women with breast cancers who underwent NAC was reviewed. The mass margin, presence of intratumoral necrosis, tumor extension around the mass, relative signal enhancement (RSE), and kinetic curve pattern were analyzed. We investigated the possible correlations between MRI findings and the effects of NAC.
An irregular mass margin was significantly associated with luminal-A cancers, while a smooth mass margin was associated with human epidermal growth factor receptor2 (HER2) cancers. Intratumoral necrosis was significantly associated with triple-negative cancers. Tumor extension around the mass was significantly infrequent in luminal-B cancers and frequent in HER2 cancers. Luminal-B and HER2 cancers showed a significantly higher RSE at 2 min than Luminal-A cancers. Estrogen receptor (ER)-positive cancers, HER2-negative cancers, and presence of intratumoral necrosis were significantly associated with the NAC non-response.
Several MR features can be used to predict the intrinsic subtype of breast cancers. ER-positivity, HER2-negativity, and presence of intratumoral necrosis were significantly associated with NAC non-response.
本研究旨在根据内在亚型评估乳腺癌的磁共振成像（MRI）特征，并探讨MRI和免疫组化结果是否与新辅助化疗（NAC）效果相关。
回顾了116例接受NAC的乳腺癌女性患者的MRI检查结果。分析了肿块边缘、瘤内坏死情况、肿块周围肿瘤扩展情况、相对信号增强（RSE）以及动态曲线模式。我们研究了MRI表现与NAC效果之间的可能相关性。
肿块边缘不规则与腔面A型癌症显著相关，而肿块边缘光滑与人类表皮生长因子受体2（HER2）型癌症相关。瘤内坏死与三阴性癌症显著相关。肿块周围的肿瘤扩展在腔面B型癌症中显著少见，而在HER2型癌症中常见。腔面B型和HER2型癌症在2分钟时的RSE显著高于腔面A型癌症。雌激素受体（ER）阳性癌症、HER2阴性癌症以及瘤内坏死的存在与NAC无反应显著相关。
几种MRI特征可用于预测乳腺癌的内在亚型。ER阳性、HER2阴性以及瘤内坏死的存在与NAC无反应显著相关。
