Sviridov L P, Stepanov A V, Konikova R E, Ustinov B S
Zh Mikrobiol Epidemiol Immunobiol. 1990 Apr(4):70-3.
The influence of prodigiosan, salmosan, polyribonate and levamisole on the body nonspecific and specific resistance to S. typhi strain 4446 has been studied. Prodigiosan and salmosan have proved to be the most effective. The injection of these compounds simultaneously with typhoid vaccine (both chemical adsorbed vaccine and alcohol-treated vaccine, enriched with Vi-antigen) significantly increases the survival rate of immunized animals (by 35-45%), elevates the resistance index (1.5- to 2.3-fold) and the effectiveness index of the vaccine (17- to 32-fold) in comparison with the controls. Besides, prodigiosan and salmosan alone are capable of increasing nonspecific resistance to S. typhi strain 4446, which is manifested by an increase of the survival rate of stimulated animals by 61.87%. Proceeding from the results thus obtained, the possibility of good prospects for prodigiosan and salmosan in the prophylaxis of typhoid fever in humans may be inferred.
研究了灵菌红素、沙门菌素、聚核糖核苷酸和左旋咪唑对机体非特异性和特异性抗伤寒杆菌4446株能力的影响。结果证明，灵菌红素和沙门菌素最为有效。将这些化合物与伤寒疫苗（化学吸附疫苗和经酒精处理、富含Vi抗原的疫苗）同时注射，与对照组相比，可显著提高免疫动物的存活率（提高35% - 45%），提升抵抗力指数（提高1.5至2.3倍）以及疫苗的效力指数（提高17至32倍）。此外，单独使用灵菌红素和沙门菌素能够增强机体对伤寒杆菌4446株的非特异性抵抗力，表现为受刺激动物的存活率提高61.87%。基于所获结果，可以推断灵菌红素和沙门菌素在预防人类伤寒方面具有良好的应用前景。
