• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

免疫调节剂对气性坏疽抵抗力的影响。灵菌红素对小白鼠抗A型产气荚膜杆菌毒素能力的增强作用

[Effect of immunomodulators on resistance to gas gangrene. The enhanced resistance of white mice to perfringens toxin type A as affected by prodigiozan].

作者信息

Konikova R E, Stepanov A V, Sviridov L P

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1986 Feb(2):81-4.

PMID:2870596
Abstract

Experiments on 575 noninbred white mice have revealed that the nonspecific resistance of the animals to type A C. perfringens toxin can be enhanced by the administration of Prodigiosan, a commercial immunostimulating agent. Prodigiosan, introduced in 3-4 injections (the last one made 24 hours before intoxication) has been found to enhance the resistance of the animals to the subcutaneous injection of type A C. perfringens toxin by 40-60% and to its intraperitoneal injection by 60-97%.

摘要

对575只非近交系白色小鼠进行的实验表明,作为一种商业免疫刺激剂的灵菌红素的给药可增强动物对A型产气荚膜梭菌毒素的非特异性抵抗力。已发现,分3至4次注射(最后一次在中毒前24小时进行)的灵菌红素可使动物对皮下注射A型产气荚膜梭菌毒素的抵抗力提高40%至60%,对腹腔注射该毒素的抵抗力提高60%至97%。

相似文献

1
[Effect of immunomodulators on resistance to gas gangrene. The enhanced resistance of white mice to perfringens toxin type A as affected by prodigiozan].免疫调节剂对气性坏疽抵抗力的影响。灵菌红素对小白鼠抗A型产气荚膜杆菌毒素能力的增强作用
Zh Mikrobiol Epidemiol Immunobiol. 1986 Feb(2):81-4.
2
[The effect of immunostimulants on the resistance of white mice to the causative agent of typhoid fever].[免疫刺激剂对小白鼠抵抗伤寒热病原体能力的影响]
Zh Mikrobiol Epidemiol Immunobiol. 1990 Apr(4):70-3.
3
Vaccines against Clostridium perfringens alpha-toxin.抗产气荚膜梭菌α毒素疫苗。
Curr Pharm Biotechnol. 2013;14(10):913-7. doi: 10.2174/1389201014666131226124348.
4
[Prolongation of the effect of immunostimulators as means of increasing resistance to causative agents of infection].
Antibiot Khimioter. 1990 May;35(5):32-5.
5
[Immunomodulating therapy of adjuvant disease in rats using cyclophosphamide in combination with prodigiozan--its effect on anti-infectious resistance].[环磷酰胺联合灵菌红素对大鼠佐剂病的免疫调节治疗——对抗感染抵抗力的影响]
Antibiot Khimioter. 1988 Jul;33(7):532-5.
6
[Influence of prodigiozan, methyluracil and levamisole on the anti-inflammatory effect of nonsteroid antiphlogistics].[灵菌红素、甲基尿嘧啶和左旋咪唑对非甾体抗炎药抗炎作用的影响]
Antibiotiki. 1984 Jun;29(6):453-6.
7
[Clostridium perfringens and gas gangrene].[产气荚膜梭菌与气性坏疽]
Zentralbl Chir. 1986;111(6):314-23.
8
Clostridium perfringens toxins (type A, B, C, D, E).产气荚膜梭菌毒素(A、B、C、D、E型)
Pharmacol Ther. 1980;10(3):617-55. doi: 10.1016/0163-7258(80)90031-5.
9
Cross-complementation of Clostridium perfringens PLC and Clostridium septicum alpha-toxin mutants reveals PLC is sufficient to mediate gas gangrene.产气荚膜梭菌磷脂酶C(PLC)和败血梭菌α毒素突变体的交叉互补表明,PLC足以介导气性坏疽。
Microbes Infect. 2009 Mar;11(3):413-8. doi: 10.1016/j.micinf.2009.01.002. Epub 2009 Jan 20.
10
Clostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis.梭菌性气性坏疽:α毒素和θ毒素对免疫反应有不同调节作用并诱导急性组织坏死的证据
J Infect Dis. 1997 Jul;176(1):189-95. doi: 10.1086/514022.