Bakulin I N, Sergeeva T I
Zh Mikrobiol Epidemiol Immunobiol. 1990 Apr(4):80-3.
A method for isolation of the ribosomal fraction (RF) from the cytoplasm of type-A C. perfringens strain BP6K was developed and its chemical and antigenic properties characterized. RF has been found to possess protective properties: two subcutaneous immunizations of mice with RF preparations adsorbed on Al(OH)3 in doses of 250 and 500 micrograms (dry weight) has ensured, on the average, the protection of 41.9% of the immunized animals from 1 DCL of type-A C. perfringens strain BP6K culture.
开发了一种从A型产气荚膜梭菌菌株BP6K细胞质中分离核糖体组分（RF）的方法，并对其化学和抗原特性进行了表征。已发现RF具有保护特性：用吸附在氢氧化铝上的RF制剂以250和500微克（干重）的剂量对小鼠进行两次皮下免疫，平均可确保41.9%的免疫动物免受1个致死剂量的A型产气荚膜梭菌菌株BP6K培养物的侵害。
