托吡酯：其在预防和治疗偏头痛中的安全性及有效性
Topiramate: safety and efficacy of its use in the prevention and treatment of migraine.
作者信息
Minton Ginger C, Miller April D, Bookstaver P Brandon, Love Bryan L
机构信息
South Carolina College of Pharmacy, University of South Carolina Campus, Columbia, SC, USA.
出版信息
J Cent Nerv Syst Dis. 2011 Jun 23;3:155-68. doi: 10.4137/JCNSD.S4365. Print 2011.
Migraine headaches are typically episodic in nature and may affect nearly 10% of the population. In addition to treatment, prevention of subsequent episodes or progression to a chronic migraine state is an important therapeutic area. Topiramate is a centrally acting medication approved for both the prevention of seizures and migraine headache. At this time, the exact mechanism of how topiramate assists in migraine prevention is unknown. Several large randomized, controlled trials have aided in establishing topiramate's role in migraine prevention. Despite a favorable pharmacokinetic and adverse effect profile established in clinical trials, several additional studies, case reports and toxicology reports have demonstrated topiramate as a cause of cognitive and behavioural changes. The use of topiramate in migraine prevention can improve a patient's quality of life and is a cost-effective option for migraine prevention.
偏头痛本质上通常是发作性的，可能影响近10%的人口。除了治疗之外，预防后续发作或进展为慢性偏头痛状态是一个重要的治疗领域。托吡酯是一种中枢作用药物，被批准用于预防癫痫和偏头痛。目前，托吡酯预防偏头痛的确切机制尚不清楚。几项大型随机对照试验有助于确立托吡酯在偏头痛预防中的作用。尽管在临床试验中已确立了良好的药代动力学和不良反应特征，但一些额外的研究、病例报告和毒理学报告表明，托吡酯可导致认知和行为改变。托吡酯用于偏头痛预防可改善患者的生活质量，是一种具有成本效益的偏头痛预防选择。
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