Escola de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Biomed Res Int. 2013;2013:472626. doi: 10.1155/2013/472626. Epub 2013 Jun 3.
The aim of this study was to characterize the penicillin-loaded microbeads composed of alginate and octenyl succinic anhydride (OSA) starch prepared by ionotropic pregelation with calcium chloride and to evaluate their in vitro drug delivery profile. The beads were characterized by size, scanning electron microscopy (SEM), zeta potential, swelling behavior, and degree of erosion. Also, the possible interaction between penicillin and biopolymers was investigated by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), and Fourier transform infrared (FTIR) analysis. The SEM micrograph results indicated a homogeneous drug distribution in the matrix. Also, based on thermal analyses (TGA/DSC), interactions were detected between microbead components. Although FTIR spectra of penicillin-loaded microbeads did not reveal the formation of new chemical entities, they confirmed the chemical drug stability. XRD patterns showed that the incorporated crystalline structure of penicillin did not significantly alter the primarily amorphous polymeric network. In addition, the results confirmed a prolonged penicillin delivery system profile. These results imply that alginate and OSA starch beads can be used as a suitable controlled-release carrier for penicillin.
本研究的目的是描述由海藻酸钠和辛烯基琥珀酸酐（OSA）淀粉组成的载青霉素微球，该微球通过氯化钙的离子预凝胶化制备，并评估其体外药物释放特性。通过粒径、扫描电子显微镜（SEM）、Zeta 电位、溶胀行为和侵蚀程度对微球进行了表征。此外，还通过差示扫描量热法（DSC）、粉末 X 射线衍射（XRD）和傅里叶变换红外（FTIR）分析研究了青霉素与生物聚合物之间可能的相互作用。SEM 显微照片结果表明药物在基质中均匀分布。此外，基于热分析（TGA/DSC），检测到微球成分之间存在相互作用。尽管载药微球的 FTIR 光谱没有显示出新的化学实体的形成，但它们证实了药物的化学稳定性。XRD 图谱表明，青霉素的掺入结晶结构没有显著改变主要的无定形聚合物网络。此外，结果证实了青霉素的控释系统具有更长的释放时间。这些结果表明，海藻酸钠和 OSA 淀粉珠可用作青霉素的合适控释载体。
