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明胶-海藻酸钠复合凝聚系统的表征

Characterization of gelatin-sodium alginate complex coacervation system.

作者信息

Shinde Ujwala A, Nagarsenker Mangal S

机构信息

Bombay College of Pharmacy, Kalina, Santacruz (East), Mumbai-400 098, India.

出版信息

Indian J Pharm Sci. 2009 May;71(3):313-7. doi: 10.4103/0250-474X.56033.

DOI:10.4103/0250-474X.56033
PMID:20490302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2865794/
Abstract

A gelatin and sodium alginate complex coacervation system was studied and an effect of pH and colloid mixing ratios on coacervation was investigated. A colloid mixing ratio at which optimum coacervation occurred varied with the coacervation pH. Viscometric, turbidity and coacervate dry yield investigations were used to investigate optimum conditions for complex coacervation. Optimum coacervation occurred at pH 3.5 at a gelatin sodium alginate ratio 4:1. Coacervate and equilibrium fluid was analyzed for gelatin and sodium alginate contents and yields calculated on the basis of chemical analysis showed that optimum coacervation occurred at 25% sodium alginate fraction at pH 3.5.

摘要

研究了明胶与海藻酸钠复合凝聚系统，并考察了pH值和胶体混合比例对凝聚的影响。发生最佳凝聚的胶体混合比例随凝聚pH值而变化。通过粘度测定、浊度和凝聚物干产率研究来考察复合凝聚的最佳条件。在明胶与海藻酸钠比例为4:1时，pH 3.5出现最佳凝聚。分析了凝聚物和平衡液中的明胶和海藻酸钠含量，基于化学分析计算的产率表明，在pH 3.5时，海藻酸钠含量为25%时出现最佳凝聚。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb6/2865794/a8fc9c1ef92b/IJPhS-71-313-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb6/2865794/5b634e54a7d3/IJPhS-71-313-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb6/2865794/a8fc9c1ef92b/IJPhS-71-313-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb6/2865794/5b634e54a7d3/IJPhS-71-313-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb6/2865794/b03a2410c24d/IJPhS-71-313-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb6/2865794/dc2b388ac627/IJPhS-71-313-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb6/2865794/d4b69fde931f/IJPhS-71-313-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb6/2865794/a8fc9c1ef92b/IJPhS-71-313-g005.jpg

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