布鲁氏菌疫苗的发展历史。
A history of the development of Brucella vaccines.
机构信息
Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Col. Sto. Tomás, 11340 México, DF, Mexico.
出版信息
Biomed Res Int. 2013;2013:743509. doi: 10.1155/2013/743509. Epub 2013 Jun 3.
Abstract
Brucellosis is a worldwide zoonosis affecting animal and human health. In the last several decades, much research has been performed to develop safer Brucella vaccines to control the disease mainly in animals. Till now, no effective human vaccine is available. The aim of this paper is to review and discuss the importance of methodologies used to develop Brucella vaccines in pursuing this challenge.
摘要
布鲁氏菌病是一种影响动物和人类健康的世界性动物传染病。在过去的几十年中，为了控制主要在动物中发生的这种疾病，已经进行了大量研究来开发更安全的布鲁氏菌疫苗。到目前为止，还没有有效的人类疫苗。本文的目的是综述和讨论在应对这一挑战时用于开发布鲁氏菌疫苗的方法的重要性。
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本文引用的文献
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Pluronic P85 enhances the efficacy of outer membrane vesicles as a subunit vaccine against Brucella melitensis challenge in mice.泊洛尼克P85增强了外膜囊泡作为抗小鼠布鲁氏菌病亚单位疫苗的效力。
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Vaccines: from empirical development to rational design.疫苗：从经验开发到理性设计。
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Invasive Escherichia coli vaccines expressing Brucella melitensis outer membrane proteins 31 or 16 or periplasmic protein BP26 confer protection in mice challenged with B. melitensis.表达布鲁氏菌属 melitensis 外膜蛋白 31 或 16 或周质蛋白 BP26 的侵袭性大肠杆菌疫苗可保护小鼠免受布鲁氏菌属 melitensis 攻击。
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