Wang Zhen, Wu Qingmin
Key Laboratory of Animal Epidemiology and Zoonosis of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Curr Pharm Biotechnol. 2013;14(10):887-96. doi: 10.2174/1389201014666131226123016.
Brucella spp. are facultative intracellular bacteria that cause brucellosis, which is a globally occurring zoonotic disease that is characterized by abortion in domestic animals and undulant fever, arthritis, endocarditis, and meningitis in humans. There are currently no licensed vaccines against brucellosis for human use, and only a few licensed live Brucella vaccines are available for use in animals. However, the available animal vaccines may cause abortion and are associated with lower protection rates in animals and higher virulence in humans. Much research has been performed recently to develop novel Brucella vaccines for the prevention and control of animal brucellosis. This article discusses the approaches and strategies for novel live attenuated vaccine development.
布鲁氏菌属是兼性胞内细菌，可引起布鲁氏菌病，这是一种全球范围内发生的人畜共患病，其特征是家畜流产以及人类出现波状热、关节炎、心内膜炎和脑膜炎。目前尚无获许可用于人类的布鲁氏菌病疫苗，仅有少数几种获许可的活布鲁氏菌疫苗可用于动物。然而，现有的动物疫苗可能会导致流产，并且在动物中的保护率较低，对人类的毒力较高。最近进行了大量研究以开发用于预防和控制动物布鲁氏菌病的新型布鲁氏菌疫苗。本文讨论了新型减毒活疫苗开发的方法和策略。
