突变型人血清白蛋白的光手性诱导：2-蒽羧酸的对映选择性光环二聚反应。
Photochirogenesis with mutant human serum albumins: enantiodifferentiating photocyclodimerization of 2-anthracenecarboxylate.
机构信息
Office for University-Industry Collaboration, Osaka University, Yamada-oka, Suita, 565-0871, Japan.
出版信息
Chem Commun (Camb). 2013 Aug 28;49(67):7433-5. doi: 10.1039/c3cc42656d.
PMID:23862178
Abstract
Mutant human serum albumins accelerated the photocyclodimerization of 2-anthracenecarboxylate to afford chiral cyclodimers in 75-85% enantiomeric excesses, revealing that the mutations to impair non-productive sites 1 and/or 2 enhanced the substrate binding to site 3 without seriously damaging its inherently high photochirogenic ability.
摘要
突变人血清白蛋白加速了 2-蒽羧酸的光环二聚化，以 75-85%的对映体过量得到手性环二聚体，表明突变以损害非生产性部位 1 和/或 2 增强了与部位 3 的底物结合，而不会严重损害其固有的高光致旋光能力。
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