视黄酸在胚胎干细胞表观遗传调控中的非经典活性。
Non-canonical activity of retinoic acid in epigenetic control of embryonic stem cell.
作者信息
Wei Li-Na
机构信息
Department of Pharmacology University of Minnesota Medical School; Minneapolis, MN USA.
出版信息
Transcription. 2013 Jul-Aug;4(4):158-61. doi: 10.4161/trns.25395. Epub 2013 Jun 14.
Abstract
Non-canonical cytoplasmic activities and signal transduction of retinoic acid (RA) expand RA's pleiotropic effects in coordinating the epigenome in embryonic stem cell (ESC). Examples include RA-bound cellular retinoic acid binding protein I, which activates ERK2. By engaging both cytosolic and nuclear mediators, RA can efficiently augment ESC's epigenome.
摘要
视黄酸（RA）的非经典细胞质活性和信号转导扩展了RA在协调胚胎干细胞（ESC）表观基因组方面的多效性作用。实例包括与RA结合的细胞视黄酸结合蛋白I，其可激活ERK2。通过与胞质和核介质结合，RA能够有效地增强ESC的表观基因组。
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