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视黄酸在胚胎干细胞表观遗传调控中的非经典活性。

Non-canonical activity of retinoic acid in epigenetic control of embryonic stem cell.

作者信息

Wei Li-Na

机构信息

Department of Pharmacology University of Minnesota Medical School; Minneapolis, MN USA.

出版信息

Transcription. 2013 Jul-Aug;4(4):158-61. doi: 10.4161/trns.25395. Epub 2013 Jun 14.

DOI:10.4161/trns.25395
PMID:23863198
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3977914/
Abstract

Non-canonical cytoplasmic activities and signal transduction of retinoic acid (RA) expand RA's pleiotropic effects in coordinating the epigenome in embryonic stem cell (ESC). Examples include RA-bound cellular retinoic acid binding protein I, which activates ERK2. By engaging both cytosolic and nuclear mediators, RA can efficiently augment ESC's epigenome.

摘要

视黄酸（RA）的非经典细胞质活性和信号转导扩展了RA在协调胚胎干细胞（ESC）表观基因组方面的多效性作用。实例包括与RA结合的细胞视黄酸结合蛋白I，其可激活ERK2。通过与胞质和核介质结合，RA能够有效地增强ESC的表观基因组。

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本文引用的文献

1
Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid.细胞视黄酸结合蛋白 I 通过全反式视黄酸介导 ERK1/2 的快速非经典激活。
Cell Signal. 2013 Jan;25(1):19-25. doi: 10.1016/j.cellsig.2012.09.002. Epub 2012 Sep 7.
2
Defining stem cell types: understanding the therapeutic potential of ESCs, ASCs, and iPS cells.定义干细胞类型：了解胚胎干细胞、间充质干细胞和诱导多能干细胞的治疗潜力。
J Mol Endocrinol. 2012 Aug 30;49(2):R89-111. doi: 10.1530/JME-12-0072. Print 2012 Oct.
3
Retinoic acid signalling during development.视黄酸信号在发育过程中的作用。
Development. 2012 Mar;139(5):843-58. doi: 10.1242/dev.065938.
4
Epigenetic control of embryonic stem cell differentiation.胚胎干细胞分化的表观遗传控制。
Stem Cell Rev Rep. 2012 Mar;8(1):67-77. doi: 10.1007/s12015-011-9300-4.
5
Physiological insights into all-trans-retinoic acid biosynthesis.全反式维甲酸生物合成的生理学见解。
Biochim Biophys Acta. 2012 Jan;1821(1):152-67. doi: 10.1016/j.bbalip.2011.05.004. Epub 2011 May 19.
6
Nuclear retinoic acid receptors: conductors of the retinoic acid symphony during development.核视黄酸受体：发育过程中视黄酸交响乐的指挥者。
Mol Cell Endocrinol. 2012 Jan 30;348(2):348-60. doi: 10.1016/j.mce.2011.03.025. Epub 2011 Apr 8.
7
Promyelocytic leukemia protein in retinoic acid-induced chromatin remodeling of Oct4 gene promoter.早幼粒细胞白血病蛋白在维甲酸诱导的 Oct4 基因启动子染色质重塑中的作用。
Stem Cells. 2011 Apr;29(4):660-9. doi: 10.1002/stem.623.
8
Epigenetic control of embryonic stem cell fate.胚胎干细胞命运的表观遗传控制。
J Exp Med. 2010 Oct 25;207(11):2287-95. doi: 10.1084/jem.20101438.
9
Extrinsic regulation of pluripotent stem cells.多能干细胞的外在调控。
Nature. 2010 Jun 10;465(7299):713-20. doi: 10.1038/nature09228.
10
A transcriptional roadmap to the induction of pluripotency in somatic cells.体细胞重编程为多能性细胞的转录调控图谱。
Stem Cell Rev Rep. 2010 Jun;6(2):282-96. doi: 10.1007/s12015-010-9137-2.