Walker Andrew M, Xiao Yao, Johnston Clifton R, Rival David E
Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, AB, Canada.
Biorheology. 2013;50(3-4):177-90. doi: 10.3233/BIR-130635.
Although information pertaining to the viscous characterization of HES 130/0.4 Voluven® and HES 260/0.45 Pentaspan® is available, quantification is limited to 100% concentrations. We focus here on the quantification of their viscous behavior along with HES 130/0.4 Volulyte® in a shear thinning non-Newtonian blood analog of aqueous xanthan gum and glycerol. Dynamic viscosities of multiple batches of HES fluids were measured through capillary viscometry. The viscous behavior of 100%, 25% and 12.5% concentrations were then measured through a closed flow loop across physiologically relevant flow rates. Measured viscosities were 2.57 millipascal second (mPa·s) 6.52 mPa·s and 2.48 mPa·s for HES 130/0.4 Voluven®, HES 260/0.45 and HES 130/0.4 Volulyte®, respectively. Pipe flow analysis found that all HES fluids displayed Newtonian behavior at 100% concentrations. 25% concentrations of both HES 130/0.4 fluids decreased analog viscosity 23%-29% at a flow rate of 1.0 ml/s and 16%-21% at a flow rate of 22.5 ml/s. At a flow rate of 22.5 ml/s, 25% and 12.5% concentrations of HES 260/0.45 resulted in analog viscosity changes of 3.9%-4.5%. Capillary viscosity reductions of approximately 7% and 14.5% in HES 130/0.4 Voluven® and HES 260/0.45 suggest changes in molecular composition to batches previously measured. Maintenance of analog viscosity suggests that HES 260/0.45 would be suitable as a high viscosity plasma expander in extreme hemodilution through preservation of microcirculatory function and wall shear stress (WSS).
虽然已有关于羟乙基淀粉130/0.4（万汶®）和羟乙基淀粉260/0.45（聚明胶肽®）粘性特征的信息，但定量仅限于100%的浓度。在此，我们重点研究它们与羟乙基淀粉130/0.4（聚乐维特®）在由黄原胶水溶液和甘油组成的剪切变稀非牛顿血液模拟物中的粘性行为定量。通过毛细管粘度测定法测量了多批羟乙基淀粉溶液的动态粘度。然后通过一个封闭流动回路在生理相关流速下测量了100%、25%和12.5%浓度的粘性行为。羟乙基淀粉130/0.4（万汶®）、羟乙基淀粉260/0.45和羟乙基淀粉130/0.4（聚乐维特®）的测量粘度分别为2.57毫帕秒（mPa·s）、6.52 mPa·s和2.48 mPa·s。管道流动分析发现，所有羟乙基淀粉溶液在100%浓度时均表现出牛顿流体行为。两种羟乙基淀粉130/0.4溶液在25%浓度时，在流速为1.0毫升/秒时模拟粘度降低23%-29%，在流速为22.5毫升/秒时降低16%-21%。在流速为22.5毫升/秒时，25%和12.5%浓度的羟乙基淀粉260/0.45导致模拟粘度变化3.9%-4.5%。羟乙基淀粉130/0.4（万汶®）和羟乙基淀粉260/0.45的毛细管粘度分别降低约7%和14.5%，这表明与之前测量的批次相比分子组成发生了变化。模拟粘度的维持表明，羟乙基淀粉260/0.45通过保留微循环功能和壁面剪应力（WSS），在极度血液稀释中适合作为高粘度血浆扩容剂。
