Toledo-Pastrana Tomás, Llombart-Cussac Beatriz, Traves-Zapata Victor, Requena-Caballero Celia, Sanmartín-Jimenez Onofre, Angeles-Sales María, Cabezas María, Guillén-Barona Carlos
*Departamento de Dermatología M. Q y V, Hospital Universitario Virgen Macarena, Sevilla, Spain; †Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain; ‡Servicio de Anatomía Patológica, Instituto Valenciano de Oncología, Valencia, Spain; §Servicio de Anatomía Patológica, Hospital Clínico de Valencia, Valencia, Spain.
Am J Dermatopathol. 2014 Oct;36(10):e175-8. doi: 10.1097/DAD.0b013e318288cdd2.
Cutaneous apocrine adenocarcinoma (CAA) is a rare adnexal neoplasm that histologically can mimic breast carcinoma metastatic to the skin or apocrine carcinoma arising in ectopic breast tissue. It can present with a wide range of clinical modalities and can often simulate many benign processes, which delays its diagnosis and hinders its prognosis. We describe a case of a 33-year-old man who had a short-evolution small nodule in the right axilla with local lymph node metastases. The immunohistochemical characterization was closer to that of breast adenocarcinoma than to an adnexal neoplasm. This was established as the main differential diagnosis. Diagnosis of cutaneous apocrine adenocarcinoma may be difficult and immunomarkers are not specific. The anatomical criteria and systemic investigation are mandatory to establish the correct diagnosis.
皮肤大汗腺癌（CAA）是一种罕见的附属器肿瘤，在组织学上可模仿转移至皮肤的乳腺癌或异位乳腺组织中发生的大汗腺癌。它可表现出多种临床形式，且常可模拟许多良性病变，这会延迟其诊断并影响其预后。我们描述了一例33岁男性患者，其右腋窝有一个病程较短的小结节，并伴有局部淋巴结转移。免疫组化特征更接近乳腺腺癌而非附属器肿瘤。这被确立为主要的鉴别诊断。皮肤大汗腺癌的诊断可能困难，且免疫标志物并不特异。解剖学标准和全身检查对于确立正确诊断至关重要。
