Kamata Arimichi, Hino Koji, Matsuda Arisa, Kamiyama Koki, Takasaka Yoshihiro, Tazawa Kenichi
Department of Breast Surgery, Tomei Atsugi Hospital, Atsugi, Kanagawa 232 Funako Japan.
Department of Pharmacy, Tomei Atsugi Hospital, Atsugi, Japan.
Int Cancer Conf J. 2024 Jul 6;13(4):348-352. doi: 10.1007/s13691-024-00700-7. eCollection 2024 Oct.
Cutaneous apocrine carcinoma (CAC) is an extremely rare skin appendage malignant tumor that develops in the apocrine sweat glands, and no evidence-based drug therapy has been established. A 61-year-old female patient was diagnosed with axillary CAC with axillary lymph node metastasis and underwent surgery. Pathological examination revealed seven lymph node metastases. Immunostaining revealed that the tumor cells were estrogen receptor (ER)-positive, progesterone receptor (PgR)-positive, and human epidermal growth factor receptor 2 (HER2)-positive. The patient received chemotherapy, including anti-HER2 drugs, and hormone therapy to prevent recurrence. No recurrence was observed for > 3 years after surgery. The apocrine glands in the skin and mammary glands have similar characteristics and mammary glands are thought to be modified or derived from the apocrine glands present in the subcutaneous adipose tissue. Therefore, ER, PgR, and HER2 levels may be positive in CAC. Drug treatments for breast cancer may also be effective for CAC.
皮肤大汗腺癌（CAC）是一种极其罕见的皮肤附属器恶性肿瘤，起源于大汗腺，目前尚未确立基于证据的药物治疗方法。一名61岁女性患者被诊断为伴有腋窝淋巴结转移的腋窝CAC并接受了手术。病理检查发现有7处淋巴结转移。免疫染色显示肿瘤细胞雌激素受体（ER）阳性、孕激素受体（PgR）阳性、人表皮生长因子受体2（HER2）阳性。该患者接受了包括抗HER2药物在内的化疗以及激素治疗以预防复发。术后超过3年未观察到复发。皮肤和乳腺中的大汗腺具有相似特征，并且认为乳腺是由皮下脂肪组织中存在的大汗腺演变或衍生而来。因此，CAC中ER、PgR和HER2水平可能为阳性。乳腺癌的药物治疗对CAC可能也有效。
