细胞凋亡的抗炎作用。
Antiinflammatory effects of apoptotic cells.
机构信息
Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
出版信息
J Clin Invest. 2013 Jul;123(7):2773-4. doi: 10.1172/JCI69344. Epub 2013 Jul 1.
Abstract
Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune responses, and the resolution of inflammation. In 1998, Peter Henson, Donna Bratton, and colleagues at National Jewish Health demonstrated that phagocytosis of apoptotic cells actively suppresses inflammation by inhibiting the production of inflammatory cytokines and inducing production of antiinflammatory factors, including TGF-β and prostaglandin E2. Here they discuss the evolving relationship among apoptosis, phagocytosis, and inflammation.
摘要
凋亡细胞会被巨噬细胞迅速吞噬，这一过程是组织重塑、免疫反应和炎症消退的关键步骤。1998 年，Peter Henson、Donna Bratton 及其在 National Jewish Health 的同事们证明，凋亡细胞的吞噬作用通过抑制炎症细胞因子的产生和诱导抗炎因子（包括 TGF-β和前列腺素 E2）的产生来积极抑制炎症。在此，他们讨论了凋亡、吞噬和炎症之间不断变化的关系。
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