Hengartner M O, Horvitz H R
Cold Spring Harbor Laboratory, New York.
Curr Opin Genet Dev. 1994 Aug;4(4):581-6. doi: 10.1016/0959-437x(94)90076-f.
Programmed cell death in the nematode Caenorhabditis elegans requires the activities of the genes ced-3 and ced-4 and is antagonized by the activity of the gene ced-9. Cloning of these C. elegans genes has shown that two of them encode proteins with similarity to vertebrate cell death genes and has revealed that nematodes and mammals share a common pathway for programmed cell death.
线虫秀丽隐杆线虫中的程序性细胞死亡需要ced-3和ced-4基因的活性，并且受到ced-9基因活性的拮抗。对这些秀丽隐杆线虫基因的克隆表明，其中两个基因编码的蛋白质与脊椎动物细胞死亡基因相似，并且揭示了线虫和哺乳动物在程序性细胞死亡方面共享一条共同途径。
