头孢克肟对来自儿科患者的流感嗜血杆菌分离株（包括耐氨苄西林、不产β-内酰胺酶的分离株）的体外活性比较
Comparative in vitro activity of cefixime against Haemophilus influenzae isolates, including ampicillin-resistant, non-beta-lactamase-producing isolates, from pediatric patients.
作者信息
Mortensen J E, Himes S L
机构信息
St. Christopher's Hospital for Children, Philadelphia, Pennsylvania 19134.
出版信息
Antimicrob Agents Chemother. 1990 Jul;34(7):1456-8. doi: 10.1128/AAC.34.7.1456.
Abstract
The in vitro activity of cefixime was comparatively tested against 232 non-type b and 102 type b isolates of Haemophilus influenzae derived from clinical specimens of pediatric patients, including 10 non-type b strains that did not produce beta-lactamase and demonstrated resistance to ampicillin. Cefixime was active against the ampicillin-susceptible and ampicillin-resistant, beta-lactamase-producing isolates; however, its activity against some non-beta-lactamase-producing, ampicillin-resistant isolates appeared to be limited.
摘要
对来自儿科患者临床标本的232株非b型和102株b型流感嗜血杆菌进行了头孢克肟体外活性的比较测试，其中包括10株不产生β-内酰胺酶且对氨苄西林耐药的非b型菌株。头孢克肟对氨苄西林敏感、氨苄西林耐药且产生β-内酰胺酶的分离株有活性；然而，其对一些不产生β-内酰胺酶且氨苄西林耐药的分离株的活性似乎有限。
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