流感嗜血杆菌对头孢克肟的体外敏感性
In vitro susceptibility of Haemophilus influenzae to cefixime.
作者信息
Powell M, Williams J D
机构信息
Department of Medical Microbiology, London Hospital Medical College, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1987 Nov;31(11):1841-2. doi: 10.1128/AAC.31.11.1841.
Abstract
The in vitro activity of cefixime against 2,458 clinical isolates of Haemophilus influenzae was determined. All the strains were inhibited by less than or equal to 2 micrograms of cefixime per ml, and the modal MIC was 0.03 micrograms/ml. Activity was unaffected by the presence of beta-lactamase produced by 157 isolates. Nineteen of the twenty-four isolates for which cefixime MICs were greater than or equal to 0.5 micrograms/ml were beta-lactamase negative but showed reduced susceptibility to ampicillin.
摘要
测定了头孢克肟对2458株流感嗜血杆菌临床分离株的体外活性。所有菌株均被每毫升小于或等于2微克的头孢克肟所抑制，众数最小抑菌浓度（MIC）为0.03微克/毫升。157株分离株产生的β-内酰胺酶的存在对活性没有影响。头孢克肟MIC大于或等于0.5微克/毫升的24株分离株中，有19株β-内酰胺酶阴性，但对氨苄西林敏感性降低。
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