Jackson S K, Parton J, Shortland G, Stark J M, Thompson E N
University of Wales College of Medicine, Heath Park, Cardiff.
Arch Dis Child. 1990 Jul;65(7):771-3. doi: 10.1136/adc.65.7.771.
Circulating antibody to endotoxin core glycolipid and total serum immunoglobulin concentrations were measured in 86 children with cancer (54 with acute lymphoblastic leukaemia, four with acute myeloid leukaemia, and 28 with various solid tumours). Measurements were made before treatment in the group with acute lymphoblastic leukaemia as well as when patients were both on and off chemotherapy. In the other two groups measurements were made when patients were both on and off treatment. Significant reductions in endotoxin antibody and serum immunoglobulin concentrations were found only in patients with acute lymphoblastic leukaemia. In addition, there was a significant correlation between febrile episodes and the concentration of antibody to core glycolipid in the children with acute lymphoblastic leukaemia. These findings suggest that the use of prophylactic high titre endotoxin antibody may be of benefit to children with life threatening Gram negative infections who are receiving cytotoxic chemotherapy.
对86名癌症患儿（54例急性淋巴细胞白血病、4例急性髓细胞白血病和28例各种实体瘤）检测了循环内毒素核心糖脂抗体和血清总免疫球蛋白浓度。对急性淋巴细胞白血病组在治疗前以及患者化疗期间和化疗间歇期进行了检测。对其他两组在患者治疗期间和治疗间歇期进行了检测。仅在急性淋巴细胞白血病患者中发现内毒素抗体和血清免疫球蛋白浓度显著降低。此外，急性淋巴细胞白血病患儿发热发作与核心糖脂抗体浓度之间存在显著相关性。这些发现表明，对于接受细胞毒性化疗且有生命危险的革兰阴性菌感染患儿，使用预防性高滴度内毒素抗体可能有益。
