Freeman R, Gould F K
Thorax. 1985 Nov;40(11):846-8. doi: 10.1136/thx.40.11.846.
Naturally occurring preoperative antibody to enteric Gram negative bacilli (Escherichia coli agglutinins or antiendotoxin, or both) in 30 patients who had had open heart surgery was associated with a significantly lower incidence of early postoperative fever and postoperative Gram negative infection than occurred in 56 patients without preoperative antibodies. The protective effect was shown to be associated with antiendotoxin rather than antibody to the somatic antigen of the bacteria. Active or passive immunisation of patients having open heart surgery against endotoxin is likely to decrease significantly the morbidity after cardiopulmonary bypass.
30例接受心脏直视手术患者体内天然存在的针对肠道革兰氏阴性杆菌的术前抗体（大肠杆菌凝集素或抗内毒素，或两者皆有），与56例无术前抗体患者相比，术后早期发热和术后革兰氏阴性感染的发生率显著降低。研究表明，这种保护作用与抗内毒素有关，而非与细菌菌体抗原的抗体有关。对接受心脏直视手术的患者进行主动或被动抗内毒素免疫，可能会显著降低体外循环后的发病率。
