Hou Hai Yan, Wang Dan, Zou Xiao Ping, Yang Zhen Hua, Li Tin-Chiu, Chen Ya Qiong
Department of Gynecology and Obstetrics, Affiliated Hospital of Chinese People's Armed Police Forces Logistics College, 220 Chenglin Road, Tianjin, 300162, People's Republic of China.
Arch Gynecol Obstet. 2014 Feb;289(2):285-91. doi: 10.1007/s00404-013-2962-1. Epub 2013 Jul 18.
To examine the associations between the ambient air pollution and early fetal loss.
A retrospective case-control study was conducted. 959 fetal losses and 959 normal intrauterine pregnancies within 14 weeks of pregnancy in 15 general or obstetrics and gynecology hospitals were selected into case and control groups, respectively. Data based on hospital records and national pollution monitor station records were collected. Logistic regression model was conducted to examine the associations between 4 ambient air pollutants (SO2, PM10, NO2 and TSP) exposures and fetal loss.
The ratio of fetal loss to termination of pregnancy for heating months (2.28 %) was significantly (P < 0.001) higher than that for the non-heating months (1.77 %). Logistic regression suggested that fetal loss within 14 weeks was associated with higher exposure to SO2 (OR = 19.76, 95 % CI 2.34-166.71) and TSP (OR = 2.04, 95 % CI 1.01-4.13) in the first month of pregnancy.
Exposure to high levels of SO2 and TSP during the first month of pregnancy was associated with an increased risk of fetal loss in early pregnancy.
研究环境空气污染与早期自然流产之间的关联。
开展一项回顾性病例对照研究。分别从15家综合医院或妇产科医院选取959例自然流产病例和959例妊娠14周内的正常宫内妊娠作为病例组和对照组。收集基于医院记录和国家污染监测站记录的数据。采用逻辑回归模型研究4种环境空气污染物（二氧化硫、可吸入颗粒物、二氧化氮和总悬浮颗粒物）暴露与自然流产之间的关联。
取暖月份的自然流产与终止妊娠的比例（2.28%）显著高于非取暖月份（1.77%）（P<0.001）。逻辑回归分析表明，妊娠第1个月内自然流产与较高水平的二氧化硫暴露（比值比=19.76，95%置信区间2.34 - 166.71）和总悬浮颗粒物暴露（比值比=2.04，95%置信区间1.01 - 4.13）相关。
妊娠第1个月接触高水平的二氧化硫和总悬浮颗粒物与妊娠早期自然流产风险增加有关。
