Sonnenfeld G, Mandel A D, Konstantinova I V, Taylor G R, Berry W D, Wellhausen S R, Lesnyak A T, Fuchs B B
Department of Microbiology and Immunology, University of Louisville School of Medicine, KY 40292.
Aviat Space Environ Med. 1990 Jul;61(7):648-53.
Experiments were carried out on cells from rats that had been flown on Soviet Biosputnik Cosmos 1887 to explore the effects of spaceflight on immune responses. Rat bone marrow cells were examined for their response to colony stimulating factor-M. Rat spleen and bone marrow cells were stained with antibodies directed against cell surface antigenic markers. The results of the studies indicate that bone marrow cells from flown rats showed a decreased response to colony stimulating factor. There was a higher percentage of spleen cells from flown rats staining positively for pan-T-cell, suppressor-T-cell and interleukin-2 receptor cell surface antigens. A small increase in the percentage of cells staining positively for helper-T-cell antigens was also noted. In addition, a higher percentage of cells that appeared to be part of the myelogenous population of bone marrow cells from flown rats stained positively for surface immunoglobulin.
对搭乘苏联生物卫星宇宙1887号飞行过的大鼠的细胞进行了实验，以探究太空飞行对免疫反应的影响。检测了大鼠骨髓细胞对集落刺激因子-M的反应。用针对细胞表面抗原标志物的抗体对大鼠脾脏和骨髓细胞进行染色。研究结果表明，飞行大鼠的骨髓细胞对集落刺激因子的反应降低。飞行大鼠脾脏细胞中，泛T细胞、抑制性T细胞和白细胞介素-2受体细胞表面抗原染色呈阳性的比例更高。还注意到辅助性T细胞抗原染色呈阳性的细胞比例略有增加。此外，飞行大鼠骨髓细胞中似乎属于骨髓细胞群体的细胞中，表面免疫球蛋白染色呈阳性的比例更高。
