Lange R D, Gibson L A, Driscoll T B, Allebban Z, Ichiki A T
Department of Medical Biology, University of Tennessee, Medical Center at Knoxville 37920.
Aviat Space Environ Med. 1994 Aug;65(8):730-5.
Astronauts have a reduction in their red cell mass when exposed to microgravity. This is probably mainly due to a physiological response to decreased energy requirements. Further studies of erythropoiesis were carried out in microgravity on rats flown on Soviet Biosatellite 2044 and in hypergravity by centrifugation at 2G. Studies included: bone marrow cell differential counts, clonal studies of RBC colony formation, and plasma erythropoietin determinations. In the bone marrow of Cosmos flight animals there was a slight increase in granulocytic cells and in centrifuged animals, a slight decrease in the percentage of erythroid cells which led to an increased M:E ratio. The bone marrow cells of flight and centrifuged rats responded to erythropoietin. Cosmos flight animals' cells formed fewer CFU-E than the controls but this was reversed in the centrifuge studies. There were no essential differences in the erythropoietin levels of test groups as compared to control groups.
宇航员在暴露于微重力环境时红细胞数量会减少。这可能主要是由于对能量需求降低的生理反应。在苏联生物卫星2044上飞行的大鼠以及在2G离心的超重力环境下，对红细胞生成进行了进一步研究。研究包括：骨髓细胞分类计数、红细胞集落形成的克隆研究以及血浆促红细胞生成素测定。在宇宙飞行动物的骨髓中，粒细胞略有增加，而在离心动物中，红系细胞百分比略有下降，导致M:E比值增加。飞行和离心大鼠的骨髓细胞对促红细胞生成素均有反应。宇宙飞行动物的细胞形成的CFU-E比对照组少，但在离心研究中这种情况得到了逆转。与对照组相比，测试组的促红细胞生成素水平没有本质差异。
