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脑缺血再灌注损伤中 TLR2 和 TLR4 的作用

TLR2 and TLR4 in the brain injury caused by cerebral ischemia and reperfusion.

机构信息

Department of Neurology, Second Affiliated Hospital of Kunming Medical University, Kunming 650031, China.

出版信息

Mediators Inflamm. 2013;2013:124614. doi: 10.1155/2013/124614. Epub 2013 Jun 23.

DOI:10.1155/2013/124614
PMID:23864765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3706022/
Abstract

Brain injury caused by cerebral ischemia/reperfusion is a complicated pathophysiological course, in which inflammation is thought to play an important role. Toll-like receptors are a type of transmembrane proteins, which can recognize either exogenous pathogen-associated molecular patterns or endogenous stress or damage-associated molecular patterns in the innate immune system and initiate inflammatory responses. Among Toll-like receptors, TLR2 and TLR4 are found to be more important than others in the pathological progression of cerebral injury due to ischemia and reperfusion. This review will focus on the biological characteristics and functions of TLR2 and TLR4 and their downstream signal pathways.

摘要

脑缺血/再灌注引起的脑损伤是一个复杂的病理生理过程，其中炎症被认为起着重要作用。Toll 样受体是一类跨膜蛋白，可在固有免疫系统中识别外源性病原体相关分子模式或内源性应激或损伤相关分子模式，并启动炎症反应。在 Toll 样受体中，TLR2 和 TLR4 被发现在缺血再灌注引起的脑损伤的病理进展中比其他受体更为重要。本综述将重点介绍 TLR2 和 TLR4 的生物学特性和功能及其下游信号通路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/431d/3706022/aeac921edfc8/MI2013-124614.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/431d/3706022/aeac921edfc8/MI2013-124614.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/431d/3706022/aeac921edfc8/MI2013-124614.001.jpg

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