茶对动物模型伤口愈合潜力的影响。
The Effect of Camellia sinensis on Wound Healing Potential in an Animal Model.
机构信息
Department of Molecular Medicine, University of Malaya Centre for Proteomics Research (UMCPR), Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
出版信息
Evid Based Complement Alternat Med. 2013;2013:386734. doi: 10.1155/2013/386734. Epub 2013 Jun 20.
Camellia sinensis (tea) is reported to have health benefits, including the building of healthy skin. This study evaluated the effects of topical application of Camellia sinensis extract on the rate of wound closure and the histology of wound area. A uniform area of 2.00 cm in diameter was excised from the neck of adult male Sprague Dawley rats. The animals were topically treated with 0.2 mL of vehicle (CMC), Intrasite gel (positive control), or 200 and 400 mg/mL of extract. Wounds dressed with the extract and Intrasite gel healed significantly earlier than those with vehicle. Histological analysis of the wound area after 10 days showed that wounds dressed with the extract had less scar width when compared to the control. The tissue contained less inflammatory cells and more collagen and angiogenesis, compared to wounds dressed with vehicle. In this study, Camellia sinensis showed high potential in wound healing activity.
茶树（茶）被报道具有健康益处，包括建立健康的皮肤。本研究评估了局部应用茶树提取物对伤口闭合率和伤口区域组织学的影响。从成年雄性 Sprague Dawley 大鼠颈部切除直径为 2.00 cm 的均匀区域。用 0.2 mL 的载体（CMC）、Intrasite 凝胶（阳性对照）或 200 和 400 mg/mL 的提取物对动物进行局部处理。用提取物和 Intrasite 凝胶处理的伤口愈合明显早于用载体处理的伤口。第 10 天对伤口区域进行组织学分析表明，与对照组相比，用提取物处理的伤口疤痕宽度更小。与用载体处理的伤口相比，组织中含有较少的炎症细胞，而含有更多的胶原蛋白和血管生成。在这项研究中，茶树表现出很高的伤口愈合活性潜力。
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