晶状体中谷胱甘肽合成的年龄相关变化。
Age-related changes in glutathione synthesis in the eye lens.
作者信息
Ferrer J V, Gascó E, Sastre J, Pallardó F V, Asensi M, Viña J
机构信息
Departamento de Fisiología, Facultad Medicina, Valencia, Spain.
出版信息
Biochem J. 1990 Jul 15;269(2):531-4. doi: 10.1042/bj2690531.
Abstract
Eye lenses from young rats or mice synthesize GSH from methionine or N-acetylcysteine. However, lenses from old animals do not synthesize GSH from methionine. This is due to the absence of cystathionase activity in old lenses. GSH monoethyl ester, but not free GSH, increases GSH content and protects the lens against experimental oxidative stress. The importance of these results in the prevention of cataractogenesis is discussed.
摘要
幼鼠或幼小鼠的晶状体可从蛋氨酸或N - 乙酰半胱氨酸合成谷胱甘肽（GSH）。然而，老年动物的晶状体不能从蛋氨酸合成GSH。这是由于老年晶状体中缺乏胱硫醚酶活性。GSH单乙酯而非游离GSH可增加GSH含量并保护晶状体免受实验性氧化应激。文中讨论了这些结果在预防白内障形成中的重要性。
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Studies on the crystalline lens. II. Synthesis of glutathione in the normal and cataractous rabbit lens.晶状体研究。II. 正常及白内障兔晶状体中谷胱甘肽的合成
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