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表面置换与传统全髋关节置换术后异位骨化的发生率:采用前外侧入路和吲哚美辛预防的对比研究。

Incidence of heterotopic ossification after surface and conventional total hip arthroplasty: a comparative study using anterolateral approach and indomethacin prophylaxis.

机构信息

Department of Orthopaedic Surgery, Azienda Ospedaliera Universitaria Integrata, Piazzale A Stefani 1, 37126 Verona, Italy.

出版信息

Biomed Res Int. 2013;2013:293528. doi: 10.1155/2013/293528. Epub 2013 Jun 24.

Abstract

The incidence and severity of heterotopic ossification (HO) in two homogeneous groups of patients that received surface replacement arthroplasty (SRA) and conventional total hip arthroplasty (THA) were evaluated retrospectively. Thirty-nine patients undergoing 42 hip resurfacing procedures and 41 primary cementless THAs through an anterolateral approach received a 10-day course of 150 mg/die of indomethacin postoperatively. The median surgical time was 190 minutes and 156 minutes, respectively (P < 0.003). At a minimum 1-year followup, the development of HO was assessed on standard X-ray using Brooker grading. Ectopic bone formation was detected in five cases (11.9%, two Brooker grade I and three grade II) in the SRA group and in 14 hips (34.1%, 12 grade I and two grade II) treated with conventional THA, but the difference was not significant (P < 0.11). No clinically relevant periprosthetic ossification (Brooker III or IV) occurred in both groups. Although the difference was not statistically significant, the incidence of HO after SRA was lower than conventional THA. More extensive soft tissue trauma, bone debris, and longer operative time in hip resurfacing are not likely to be absolute risk factors for HO. Further investigations including larger patient populations are needed to confirm these findings.

摘要

回顾性评估了接受表面置换关节成形术(SRA)和传统全髋关节置换术(THA)的两组同质患者中异位骨化(HO)的发生率和严重程度。42 例髋关节表面置换术和 41 例经前外侧入路行初次非骨水泥 THA 的患者,术后均接受 10 天 150mg/die 的吲哚美辛治疗。中位手术时间分别为 190 分钟和 156 分钟(P<0.003)。在至少 1 年的随访中,使用布鲁克分级标准在标准 X 线上评估 HO 的发展情况。在 SRA 组中,有 5 例(11.9%,2 例布鲁克 I 级和 3 例 II 级)和在接受传统 THA 治疗的 14 髋中(34.1%,12 例 I 级和 2 例 II 级)检测到异位骨形成,但差异无统计学意义(P<0.11)。两组均未发生临床相关的假体周围骨化(布鲁克 III 或 IV 级)。尽管差异无统计学意义,但 SRA 后 HO 的发生率低于传统 THA。髋关节表面置换术软组织创伤更广泛、骨屑更多和手术时间更长不太可能是 HO 的绝对危险因素。需要进一步包括更大患者群体的研究来证实这些发现。

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