G6PD缺乏症患者溶血性贫血的预后。红细胞年龄组生化特征的多因素聚类分析。

Prognosis of hemolytic anemia in G6PD- subjects. Multifactorial cluster analysis of biochemical characteristics of red cell age groups.

作者信息

Yermakov N V, Jacobasch G, Krekhnov B V, Ermakova T A

机构信息

Institute of Applied Molecular Biology MPH, Moscow, USSR.

出版信息

Biomed Biochim Acta. 1990;49(2-3):S242-6.

PMID:2386512

Abstract

Individual susceptibility of 10 G6PD- hemizygotes to oxidative hemolytic agents was tested on the basis of multifactorial cluster analysis of biochemical indices of erythrocyte populations; the indices related to G6PD activity and glucose metabolism were analyzed under physiological and oxidative stress conditions in very young, exactly adult and very old red cell suspensions. Biochemical images of G6PD- erythrocytes were obtained and compared with the donor (7 subjects) biochemical image on a IBM-PC computer according to a special "taxon" program. As a result, a stable subdivision of 10 Gd- biochemical images into 5 taxons was formed; each taxon included G6PD subjects with a certain form of clinical appearance of G6PD deficiency. Multifactorial cluster analysis of biochemical data on the erythrocyte population allows a clinical prognosis for G6PD- subjects.

摘要

基于红细胞群体生化指标的多因素聚类分析，对10名葡萄糖-6-磷酸脱氢酶（G6PD）半合子个体对氧化溶血剂的个体易感性进行了测试；在非常年轻、成年和非常年老的红细胞悬液的生理和氧化应激条件下，分析了与G6PD活性和葡萄糖代谢相关的指标。根据一个特殊的“分类”程序，在IBM-PC计算机上获得了GPD-红细胞的生化图像，并与供体（7名受试者）的生化图像进行了比较。结果，10个Gd生化图像稳定地细分为5个分类单元；每个分类单元包括具有某种形式G6PD缺乏临床表现的G6PD受试者。对红细胞群体生化数据的多因素聚类分析可为G6PD受试者提供临床预后。